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Non-aqueous acid-base titration

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8.000.6024EN Fully automated sample preparation for the content determination of tablets  
Fully automated sample preparation for the content determination of tablets

Benzbromaron is one of the main uricosuric drugs currently used. In addition to sophisticated and expensive LC-MS and GC-MS methods, benzbromaron can be effectively determined by titration with sodium hydroxide solution using a straightforward, fully automated sample preparation method. A high-frequency homogenizer comminutes one or three tablets within 90 or 120 s respectively. The overall analysis time is 8 minutes. Ten-fold determinations with one and three tablets resulted in a benzbromaron content of 99.2 and 98.7 mg per tablet respectively. Increasing the number of tablets from one to three lowers the RSD from 1.36 to 0.88%. These results show an excellent agreement with the benzbromaron content indicated by the manufacturer (approx. 100 mg/tablet).
Besides the presented Titrando/homogenizer combination, the other two members of the 815 Robotic Soliprep Sample Processor family offer comprehensive sample preparation possibilities within the fields of IC, HPLC, ICP or voltammetry.


English:  tp-t-automated sample preparation of tablets.pdf (215 KB)

Industry
Pharmaceutical Industry > Pharmaceuticals
 
Methods
Titration > Potentiometric titration > Non-aqueous acid-base titration
   Fully automated sample preparation for the content determination of tablets