Karl Fischer water determination in pharmaceuticals using the oven method
According to the 9th edition of the German Pharmacopoeia (DAB 9) the water content of a large number of drugs can be determined by Karl Fischer titration. In substances that are either difficult or impossible to dissolve in methanol, the water content is determined from the loss in weight on heating in a drying oven (drying oven method).
When compared with the drying oven method, the Karl Fischer water determination by the oven method offers decisive advantages:
- Smaller sample weights
- Far less time required
- Only water is determined; in the drying oven method other volatile compounds/contaminants are also determined at the temperature applied.
Dr. K.-H. Surborg and Ms. A. Junkersdorf at the Pharmaceutical Institute of the University of Bonn have analyzed 34 substances in 3-fold determinations. The results are given in this Bulletin in tabular form.
Industry
Pharmaceutical Industry > Pharmaceuticals
Methods
Karl Fischer Titration > Karl Fischer Oven Method
|