AB 201-300

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AB-252 Validation of Metrohm titrators (potentiometric) according to GLP/ISO 9001  
Validation of Metrohm titrators (potentiometric) according to GLP/ISO 9001

GLP (Good Laboratory Practice) requirements include the periodic check of analytical instruments for reproducibility and accuracy using standard operating procedures (SOP).
The user is advised to validate the Metrohm titrators as a complete, integrated titration system, i.e. to perform a series of titrations using standard titrimetric substances (primary standards) and critically assess the results using statistical methods.
Checking of the electronic and mechanical componentries of measuring instruments can and should be undertaken by qualified personnel of the manufacturing company as part of regular servicing. All Metrohm instruments are provided with start-up test routines which check that the relevant assemblies are working perfectly when the instrument is switched on. If no error message is displayed, it can be assumed that the instrument is functioning faultlessly.
As a guideline for the preparation of standard operating procedures to check a titration system comprising a titrator, dispensing unit, measuring chain and possibly a sample changer, Metrohm suggests the procedure described below. The limiting values specified must be considered as recommendations. Specific limiting values must be defined in the particular standard operating procedure regarding in-house requirements to the demanded accuracy of the measurement system.


English:  AB_252_2_e.pdf (142 KB)
:  AB_252_2_d.pdf (248 KB)

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Titration > Potentiometric titration > Aqueous acid-base titration
Titration > Potentiometric titration > Non-aqueous acid-base titration
Titration > Potentiometric titration > Other potentiometric titrations
Titration > Potentiometric titration > Surfactant titration
   Validation of Metrohm titrators (potentiometric) according to GLP/ISO 9001